Children with Kawasaki-like symptoms could possibly be related to COVID-19

Carsten Sauer Mikkelsen | maj 2020 | Dermatologi | COVID-19 |

Carsten Sauer Mikkelsen
Specialist in Dermato-venereology,
Private Practice in Dermato-venereology,
Brønderslev, Denmark
& Research lab.
Department of Dermato-venereology,
Aalborg University Hospital, Denmark

Kristian Bakke Arvesen
Specialist in Dermato-venereology,
Research lab.
Department of Dermato-venereology,
Aalborg University Hospital, Denmark

Peter Bjerring
Specialist in Dermato-venereology,
Research lab.
Department of Dermato-venereology,
Aalborg University Hospital, Denmark

Luit Penninga
Specialist in Surgery,
Ilulissat Hospital,
Avannaa Region,
Ilulissat, Greenland

As the COVID-19 pandemic continues, it becomes clear that COVID-19 causes a broad spectrum of symptoms and diseases. In the beginning, COVID-19 was primarily considered to be a viral pneumonia, but now we learn that this novel coronavirus infection causes many different diseases, and affects many organ systems. In this COVID-19 perspective 3 specialists in dermato-venereology and 1 specialist in surgery report and review a very recent observation: Severe disease with Kawasaki-like symptoms in children, and a possible association with COVID-19. Reports from Europe England’s medical director of the national health system (NHS), Stephen Powis, announced at the British briefing that he had become aware of reports of severely ill children with Kawasaki-like symptoms in the past few days. Though, he stressed that it was too early to determine a link with the coronavirus. The British Minister of Health, Matt Hancock, confirmed the findings with Kawasaki-like symptoms in children including death possible related to COVID-19. Similar information has been reported by Italian paediatricians. A hospital in Bergamo, northern Italy, has had more than 20 cases of severe vascular inflammation children in the past month, six times as many as expected to see in one year, according to paediatric heart specialist Matteo Ciuffreda. Paediatric cardiologists in Madrid and Lisbon have seen similar cases. Matteo Ciuffreda aims to publish the results of the Italian cases in a scientific journal. The aetiology of Kawasaki disease is unknown. It is thought to be an overreaction of the immune system following a mild infection.1-9 One study linked Kawasaki disease 16 years ago to another known coronavirus,10 though five other studies could not confirm this association of Kawasaki disease and Coronavirus NL63.11 The research 16 years ago was carried out after Coronavirus NL63 was found in a baby showing symptoms of Kawasaki disease in 2004. Ian...