AML: Significant antiproliferative effect in vitro by pharmacological Rac1 inhibition

This Norwegian study from Haukeland University Hospital, Bergen, illuminates inhibition of RAS related C3 botulinum toxin substrate 1, Rac1, on cell samples from patients with AML. Rac1 is a GTPase signal molecule which is overrepresented in several solid cancers and leukemia and has a role in migration, adhesion, and proliferation of the malign cells. New studies have shown that Rac1 also has a role in AML. In addition to this, in vitro studies have shown that Rac1 inhibition induces apoptosis and the sensivity to chemotherapy.
In this MEDtalk Anette Lodvir Hemsing, Leukemia Group at Bergens University, presents the results of Rac1 inhibition of cell samples from 79 patients with AML.