Does EVI1 Proto-oncogene Play a Role in the Initiation of MLL-AF9 AML?

In rare cases of acute myeloid leukemia (AML) driven by MLL-AF9 fusion gene, high level of proto-oncogene EVI1 expression are seen. But does EVI1 play a role in the initiation of MLL-AF9 AML? In this MEDtalk, Hugues-Etienne Chatel-Soulet, Ph.D. student from Switzerland, discusses his views on the topic, based on his lab results and a cellular model able to modify stem cells to express EVI1.