ECCO 2019: IBD cancer and serious infections in Europe (I-CARE study)
Prospective studies specifically assessing the effectiveness and safety profile of current therapeutic strategies based on a wider use of biologics in inflammatory bowel disease (IBD) are lacking. The overall objectives of I-CARE -a European prospective observationalstudy -are to assess:
1) the long-term safety profile (malignancy, infections) of immunomodulators (IMM), biologics (anti-TNF and vedolizumab) alone or in combination with an Iimmunomodulator
2) the potential for disease modification of biologics
3) the benefit-risk ratio of current therapeutic strategies
4) health economics of IBD care